This highly abundant virus in humans can act as biomarker for Covid

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Sao Paulo, Nov 8 | People infected with SARS-CoV-2 are more likely to have increased load of Torquetenovirus (TTV), an apparently inoffensive virus most frequently found in humans, which can be used as a marker of Covid-19 severity and recovery, according to researchers.

Besides humans, TTV is also common in monkeys and domestic animals. Its presence has not been associated with any known disease, but it’s excessive replication is a sign that something is wrong with the immune system.

The correlation between high TTV load and immunosuppression has been used in medicine in certain contexts, such as monitoring transplant patients who take medication to prevent rejection of the transplanted organ.

A study by researchers at the University of Sao Paulo (USP) in Brazil analysed samples from 91 patients diagnosed with SARS-CoV-2 by RT-PCR, and from 126 people with flu symptoms who tested negative. TTV and SARS-CoV-2 viral loads were measured in saliva samples.

The results, reported in the journal PLOS ONE, showed that TTV titer is higher in subjects infected by the novel coronavirus. The higher the titer, the longer they remained sick and the symptoms disappeared as viral load decreased.

None of the participants had diseases that cause immunosuppression, such as cancer or HIV/AIDS.

“Covid-19 appears to lead to a degree of immunodepression by causing an immune system imbalance, and this favours replication of TTV. In uninfected subjects, TTV titer remained stable throughout the symptomatic period,” said Maria Cassia Mendes-Correa, Professor at the Medical School (FM-USP).

While the discovery has no direct clinical applications, it may in future contribute to improved Covid-19 diagnosis and prognosis.

TTV has been analysed as a potential biomarker for certain clinical outcomes measured in different biological fluids. The researchers have investigated how elimination of SARS-CoV-2 varies over time in different body fluids, such as blood, urine and saliva.

“We then had the idea of analysing TTV load in these samples in order to find out whether it correlated with Covid-19 severity. The results showed that TTV can indeed serve as a marker of the progression and outcome of this disease. The more symptomatic the patient, the higher the TTV load in the sample,” Mendes-Correa said.

Source: IANS

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Weekly Technical Share Market Outlook

Weekly Technical Share Market Outlook

The Indian market recovered sharply on the last trading day amid the weekend after a continuous fall. Market has managed to halt above 16000 Nifty levels after continuous losing streak. Index reacted violently, grasping Indian as well as global factors throughout the week. Simultaneously, Inflation is catching up and profit margins are taking a hit.

 

Sensex advanced 1532 points or 2.90 percent while Nifty gained 484 points or 3.07 percent in a week. Simultaneously, Bank nifty has overcome bear’s dominance ending the session with 3.49 percent gain. Sectorally,Nifty Metal saw the highest gains of 7.40 percent followed by the Realty and Auto added over 4% gain. On the flip side Nifty IT tumbled 2.82 percent on weekly basis. Midcap and Small Cap measures rising nearly 2 percent as well.

In Nifty stock, EICHERMOT gained 11.31% while TECHM lost 5.98% on a weekly basis. INDIA VIX closes at 23.10 suggests volatility driven market is going to remain intact. Coming to the OI Data, on the call side highest OI witnessed at 17000 Nifty followed by 16800 Nifty strike price while on the put side, the highest OI was at 16000 Nifty followed by 15800 Nifty strike price. Technically, Nifty has formed a Tweezer Bottom type pattern in the weekly chart suggesting a short term buying rally may drive the market until monthly expiry. On the daily chart, price has rebounded from the lower Bollinger band as well.

Momentum indicators MACD & Stochastic were trading with a positive crossover & reversed from oversold zone. However, Index is still struggling to get the support of 50 Simple Moving Average in daily chart. Short term investors and traders are advised to work with option strategies to neutralize the volatility. Overall, Nifty is having support at 15700 mark while on the upside 16700 followed by 16500 may act as an immediate resistance. While Bank nifty has support around 32500 while resistance is placed at 36000 on weekly chart.

Sumeet Bagadia
Executive Director
Choice Broking

Source: Choice India

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