Stem cell therapy repairs damaged heart, spurs hope for heart attack patients

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London, May 13 | A team of German, Swedish, and British scientists has developed a new stem cell therapy which can repair a damaged heart, following a heart attack.

Although a human heart has the ability to make new muscle and possibly repair itself, the rate of regeneration is so slow that it can’t fix the kind of damage caused by a heart attack. A heart attack also creates scar tissue in place of working muscle tissue, which is less elastic.

But, the team, including scientists at AstraZeneca in collaboration with the Technical University of Munich (TUM), Karolinska Institutet, and Procella Therapeutics, a Swedish biotech, created a new stem cell therapy using human ventricular progenitor (HVP) cells to help pig hearts to repair itself.

HVP cells are known to play a crucial role in formation of the heart during embryonic development.

In the study, published in Nature Cell Biology, the team used pig models with acute injury and chronic ischemic heart failure. They demonstrated that HVP cells helped regenerate a healthy cardiac tissue following a heart attack. The therapy also showed to improve cardiac function and reduce scar tissue.

“Our research team was able to demonstrate in a laboratory setting how HVP cells can migrate to damaged regions of the heart, mature into healthy working heart cells, while preventing the formation of scar tissue,” said Karl-Ludwig Laugwitz, Professor of Cardiology at TUM.

“These findings highlight a significant milestone in the potential therapeutic use of HVP cells in the treatment of patients with serious heart failure, especially amongst older populations for whom heart surgery may represent an excessive strain in recovery,” Laugwitz said.

The team hopes to start clinical studies in humans within the next two years.

The researchers said their results show that damage to the heart can be reliably repaired even in large animals with no serious side effects observed.

The team used pigs to study the effectiveness of treating a damaged heart because of their physiological similarity to humans.

The study “provides new hope for the millions of patients worldwide with end-stage heart failure waiting for a heart transplant”, said Kenneth R. Chien, Professor of Cardiovascular Research at Karolinska Institutet.

Source: IANS

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Weekly Technical Share Market Outlook

Weekly Technical Share Market Outlook

The Indian market recovered sharply on the last trading day amid the weekend after a continuous fall. Market has managed to halt above 16000 Nifty levels after continuous losing streak. Index reacted violently, grasping Indian as well as global factors throughout the week. Simultaneously, Inflation is catching up and profit margins are taking a hit.

 

Sensex advanced 1532 points or 2.90 percent while Nifty gained 484 points or 3.07 percent in a week. Simultaneously, Bank nifty has overcome bear’s dominance ending the session with 3.49 percent gain. Sectorally,Nifty Metal saw the highest gains of 7.40 percent followed by the Realty and Auto added over 4% gain. On the flip side Nifty IT tumbled 2.82 percent on weekly basis. Midcap and Small Cap measures rising nearly 2 percent as well.

In Nifty stock, EICHERMOT gained 11.31% while TECHM lost 5.98% on a weekly basis. INDIA VIX closes at 23.10 suggests volatility driven market is going to remain intact. Coming to the OI Data, on the call side highest OI witnessed at 17000 Nifty followed by 16800 Nifty strike price while on the put side, the highest OI was at 16000 Nifty followed by 15800 Nifty strike price. Technically, Nifty has formed a Tweezer Bottom type pattern in the weekly chart suggesting a short term buying rally may drive the market until monthly expiry. On the daily chart, price has rebounded from the lower Bollinger band as well.

Momentum indicators MACD & Stochastic were trading with a positive crossover & reversed from oversold zone. However, Index is still struggling to get the support of 50 Simple Moving Average in daily chart. Short term investors and traders are advised to work with option strategies to neutralize the volatility. Overall, Nifty is having support at 15700 mark while on the upside 16700 followed by 16500 may act as an immediate resistance. While Bank nifty has support around 32500 while resistance is placed at 36000 on weekly chart.

Sumeet Bagadia
Executive Director
Choice Broking

Source: Choice India

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