Rodents maybe asymptomatic carriers of SARS-like coronaviruses: Study

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New York, Nov 19 | Some ancestral rodents likely had repeated infections with SARS-like coronaviruses, leading them to acquire tolerance or resistance to the pathogens, raising the possibility that modern rodents may be reservoirs of SARS-like viruses, according to a new study.

In the study, researchers at the Princeton University in the US, performed an evolutionary analysis of the ACE2 receptors used by SARS viruses to gain entry into mammalian cells, across mammalian species.

The results, published in the journal PLOS Computational Biology, showed that primates had highly conserved sequences of amino acids in the sites of the ACE2 receptor known to bind SARS viruses.

Rodents, however, had a greater diversity, and an accelerated rate of evolution, in these spots.

Overall, the results indicated that SARS-like infections have not been evolutionary drivers in primate history, but that some rodent species have likely been exposed to repeated SARS-like coronavirus infections for a considerable evolutionary period.

Some rodent species may have acquired some form of tolerance or resistance to infections from SARS-like coronaviruses, while non-adapted mammals and primates may be more susceptible to symptomatic disease.

“Our study suggests that ancestral rodents may have had repeated infections with SARS-like coronaviruses and have acquired some form of tolerance or resistance to SARS-like coronaviruses as a result of these infections,” said Sean King, from the varsity’s Department of Molecular Biology.

“This raises the tantalizing possibility that some modern rodent species may be asymptomatic carriers of SARS-like coronaviruses, including those that may not have been discovered yet,” added Mona Singh from the Lewis-Sigler Institute for Integrative Genomics at Princeton

While all previous human coronaviruses have clear zoonotic origins, some studies and experts have claimed that SARS-CoV-2, the virus that causes Covid-19 infection, has also jumped from a non-human animal to humans.

Previous research has shown that Chinese Horseshoe bats are a host of numerous SARS-like viruses and tolerate these viruses without extreme symptoms. Thus, identifying other animals that have adapted tolerance mechanisms to coronaviruses is important for awareness of potential viral reservoirs that can spread new pathogens to humans, the researchers said.

Source: IANS

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Share Market Closing Bell: Nifty ends above 15,800, Sensex gains 180 pts

Share Market Closing Bell: Nifty ends above 15,800, Sensex gains 180 pts

The benchmark Indices Nifty started on the positive side after continuous sell off in last week and has managed to settle at 15842.30 with 60 point gain or 0.38 percent. However Nifty has failed to regain 16000 levels prior to LIC listing.

While Bank nifty has managed to settle at 33597.60 levels after gaining 1.44 percent. On the sectoral front, Nifty PSU Bank, Nifty Realty and Auto have contributed 2-3 percent gain on closing basis. On the flip side Nifty IT and FMCG ended with losses of 0.75 percent and 0.35 respectively. In Nifty, EICHERMOT, APOLLOHOSP and UPL were the top gainers while ULTRACEMCO, SHREECEM and ASIANPAINT were the prime laggards.

Technically, after forming the bearish candle on the weekly chart, the index has formed a Doji candlestick on the daily chart which shows indecisiveness among the trades. Moreover, the index has also faced a resistance from falling trend lines and showed profit booking from higher levels. However, Fibonacci retrenchment also has support around 15650 levels.

Traders may find buying opportunities for short term as if 15650 levels is protected. In the hourly chart, with support of the middle Bollinger band short term upside movement is expected. Stock specific action would drive the market in coming days too.

On the derivatives front, the highest call OI is at 16000 strike price followed by 16200 strike prices while on the put side, highest OI is at 15500 strike price. INDIA VIX closed at 24.53 with gain of 4.43 percent intraday indicating volatility is going to remain till weekly expiry . On the other hand, Bank nifty has support at 32600 levels while resistance is placed at 34500 levels.

Sumeet Bagadia
Executive Director
Choice Broking

Source: Choice India

 

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