Pfizer, Moderna Covid shots delay response in blood cancer patients

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New York, June 29 | Covid-19 vaccines are highly effective in preventing severe infections or death, but patients with multiple myeloma — a type of blood cancer — are immunocompromised and often on immunosuppressive therapy.

The mRNA-based Pfizer and Moderna Covid vaccines evoked a lower and delayed response in them compared to healthy people, finds a study, asserting need for monitoring or continued precautions in patients with cancers.

Researchers from the Icahn School of Medicine at Mount Sinai found that almost 16 per cent of patients with multiple myeloma developed no detectable antibodies after both vaccine doses. These findings may be relevant to other cancer patients undergoing treatment and to immunocompromised patients. The study will be published in Cancer Cell.

“This study underscores the need for routine blood tests on multiple myeloma patients after vaccination to understand their risk and potential need to continue wearing masks and socially distance until the pandemic wanes,” said Samir Parekh, Professor of Medicine (Hematology and Medical Oncology), and Oncological Sciences, at Mount Sinai.

“This also calls for clinical trials to study the use of prophylactic therapies, like monoclonal antibodies, to mitigate Covid-19 risk or to use different vaccines or booster vaccinations in these patients,” he added.

Repeat antibody measurements from before patients’ first vaccine dose until 60 days after the second vaccination showed delayed and suboptimal responses, particularly in patients with multiple myeloma who had not contracted Covid-19 before their vaccinations.

Patients on active cancer treatment had significantly lower antibody levels after two vaccine doses than multiple myeloma patients who were not on treatment at the time of vaccination, the researchers said.

The team analysed the antibody levels of 320 multiple myeloma patients, 260 of whom received two doses of Covid-19 vaccinations, and found that 15.8 per cent had undetectable antibodies.

The multiple myeloma patients who had had Covid-19 before vaccination showed immune responses that were 10 times higher than those who had not.

Source: IANS

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Share Market Closing Bell: Nifty ends above 15,500, Sensex gains 443 pts

Share Market Closing Bell: Nifty ends above 15,500, Sensex gains 443 pts

On a weekly expiry day, Nifty opened on positive note and have a dip to make an intraday low at 15367.50 level but showed bounce back moment as managed to close at 15556.65 level with a gain of 143 points. Bank Nifty closed the session at 33135 level with a gain of 289.70 points. 45 Out of Nifty 50 ended in green which suggest broad based buying.

All the sectoral indices managed to close in green expect Energy while Nifty Auto was top gainer. Among Nifty Stock, MARUTI, EICHERMOT, HEROMOTOCO & M&M were the top gainers, While RELIANCE, COALINDIA, POWERGRID & GRASIM were the prima laggards. India VIX closed at 20.88 level with a loss of 1.97%. On Technical Front, The Nifty has formed bullish candle but faced resistance at 21 Four-Hourly Moving Average i.e., 15647 which suggest crossing above the same can show more upside rally.

Nifty has been trading in range of 15200-15700 level while breaching either side can suggest further direction of breakouts. Nifty has given above 50-Hourly Moving Averages which indicate it can show upside moment in the counter. On the Nifty OI Data, On the call side ,the highest OI witnessed at 16000 level while on the put side was at 15500 Niftg level followed by 15300 levels. The momentum indicators Stochastic is trading with a positive crossover on a daily chart which suggest northward journey in the Nifty.

The Nifty may find support around 15200 levels while on the upside 15700 may act as an immediate hurdle. On the other hand, Bank Nifty has support at 32300 levels while resistance at 33800 levels.

Overall, Sector specific momentum has been observed, crossing above 15700 Nifty can show more upside rally.

Market entering into buy on dips pattern.

Palak Kothari
Senior Technical Analyst
Choice Broking

Source: Choice India

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The information contained in this post is source form the news agency or PR agency. We do not take any responsibility of accuracy of information. We have not made any modification or changes in original source content. This information only for general information purposes only. The information is provided by BhaskarLive.in and while we Endeavour to keep the information up to date and correct, we make no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability, suitability or availability with respect to the website or the information, products, services, or related graphics contained on the post for any purpose.

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