mRNA Covid jabs as 2nd dose may generate robust immune response

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London, Oct 18 | People who had received a first dose of the Oxford-AstraZeneca Covid-19 vaccine and received an mRNA shot for their second dose had a lower risk of infection compared to people who had received both doses of only the Oxford-AstraZeneca vaccine, according to a study.

The study, published in the journal The Lancet Regional Health – Europe, points out the high effectiveness of mix-and-match Covid-19 vaccines.

Ateam from Umea University, Sweden conducted a study of about 700,000 individuals, and showed a 67 per cent lower risk of infection for people who received the combination of Oxford-AstraZeneca plus Pfizer-BioNTech, and a 79 per cent lower risk for Oxford/AstraZeneca and Moderna, both compared to unvaccinated individuals.

For people having received two doses of the Oxford-AstraZeneca vaccine, the risk reduction was 50 per cent. These risk estimates were observed after accounting for differences regarding date of vaccination, age of the participants, socioeconomic status, and other risk factors for Covid-19.

“Having received any of the approved vaccines is better compared to no vaccine, and two doses are better than one,” said Peter Nordstrom, Professor of geriatric medicine at Umea University.

“However, our study shows a greater risk reduction for people who received an mRNA vaccine after having received a first dose of a vector-based vaccine, as compared to people having received the vector-based vaccine for both doses,” he added.

Importantly, the estimates of effectiveness apply to infection with the Delta variant, which was dominating the confirmed cases during the follow-up period. There was a very low incidence of adverse thromboembolic events for all vaccine schedules.

Previous research has demonstrated that mix-and-match vaccine schedules generate a robust immune response. However, it has been unclear to which extent these schedules may reduce the risk of clinical infection.

“The findings of this study suggest that the use of heterologous Oxford-AstraZeneca and mRNA prime-boost vaccination is an effective alternative to increase population immunity against Covid-19, including against the Delta variant which dominated the confirmed cases during the study period,” the researchers said.

“These findings could have important implications for vaccination strategies and logistics, and consequently in the battle against the Covid-19 pandemic,” they added.

Source: IANS

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Military chopper crashes in TN Gen Bipin Rawat on board (2nd Ld)

Military chopper crashes in TN Gen Bipin Rawat on board (2nd Ld)

New Delhi, Dec 8 | Military chopper crashes in TN Gen Bipin Rawat on board (2nd Ld). A military chopper crashed in Tamil Nadu’s Coonoor on Wednesday in which Indian’s Chief of Defence Staff General Bipin Rawat was travelling along with others.

The number of casualties are still unknown and local police has ascertained only three rescued and searches are on for others.

Along with General Rawat, his wife Madhulika Rawat, Brigadier L.S. Lidder, Lieutenant Colonel Harjinder Singh, Naik Gursewak Singh, Naik Jitender Kumar, Naik Vivek Kumar, Naik B. Sai Teja, Havaldar Satpal and pilots were travelling in the chopper.

Confirming about General Rawat presence, Indian Air Force tweeted, “An IAF Mi-17V5 helicopter, with CDS Gen Bipin Rawat on board, met with an accident today near Coonoor, Tamil Nadu.”

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The force said that an inquiry has been ordered to ascertain the cause of the accident.

The rescued suffered serious injuries and have been taken to Wellington cantonment.

Source: IANS

Next Story

Military chopper crashes in TN Gen Bipin Rawat on board (Ld)

Military chopper crashes in TN Gen Bipin Rawat on board (Ld)

New Delhi, Dec 8 | Military chopper crashes in TN Gen Bipin Rawat on board (Ld). A military chopper crashed in Tamil Nadu’s Coonoor on Wednesday in which Indian’s Chief of Defence Staff General Bipin Rawat was travelling along with 14 others.

The number of casualties are still unknown and local police have ascertained only three rescued and searches are on for others.

Emergency rescue teams have been rushed to the spot.

 Military chopper crashes in TN Gen Bipin Rawat on board (2nd Ld)

Confirming about General Rawat’s presence, Indian Air Force said, “An IAF Mi-17V5 helicopter, with CDS Gen Bipin Rawat on board, met with an accident today near Coonoor, Tamil Nadu.”

The force said that an inquiry has been ordered to ascertain the cause of the accident.

The rescued suffered serious injuries and have been taken to Wellington cantonment.

Source: IANS

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