Indian-origin researchers use bovine adenovirus to develop Covid vax

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    New York, Oct 8 | A team of Indian-origin researchers in the US is working to develop a unique Covid-19 vaccine that uses a bovine adenovirus that will protect all segments of the population, especially older adults.

    Bovine Adenovirus, also known as BAdV, is a member of the Adenoviridae family that causes disease in cattle.

    “Adenoviral vectors have emerged as a promising gene-delivery platform for a variety of therapeutic and vaccine purposes during the last two decades,” said study author Suresh Kuchipudi from Penn State University in the US.

    “Historically, we have used human adenoviruses as platforms for vaccine delivery, but using a delivery system based on an animal adenovirus means that the human population will have no pre-existing immunity to the vector, thereby improving its effectiveness,” Kuchipudi added.

    Kuchipudi explained that human adenoviruses are widespread and can cause common illnesses such as cold-like symptoms, fever, sore throat, bronchitis, pneumonia, diarrhea and pink eye.

    As a result, most people may have pre-existing immunity that could impact the efficacy of vaccines delivered via a human adenovirus-based vector.

    The team, which is led by Purdue University virologist Suresh Mittal and also includes immunologist Suryaprakash Sambhara from the Centers for Disease Control and Prevention, has adapted an adenovirus typically found in cattle to prevent it from replicating, which enhances safety.

    The researchers also modified the adenovirus to express a peptide that stimulates a robust immune response to influenza viruses in mice.

    “Our preliminary work has revealed that this novel vaccine platform provides significantly higher levels of immunity compared to that of human adenovirus vectors,” Kuchipudi said.

    “We hypothesise that immunization with this vector expressing relevant antigens of SARS-CoV-2 will strengthen an effective anti-Covid-19 immunity,” Kuchipudi added.

    The researchers noted that because SARS-CoV-2 is a newly emerged virus for which humans have no previous immunity, any vaccine will have to be highly immunogenic to provide protection, particularly among older adults, whose immune systems naturally decline with age.

    “This work suggests that the bovine adenovirus vector system could serve as an excellent delivery vehicle for the development of recombinant vaccines against emerging pathogens — for the elderly and other segments of the population,” Kuchipudi said.

    “We believe this effort will yield an effective Covid-19 vaccine and could make a significant contribution to flattening the pandemic’s trajectory and helping to manage its second wave,” the study author noted.

    Source: IANS

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    Social Media Expert And Founder Of Aapno Rajasthan Durgesh Dhaker Gives His Two Cents On Growing One's Reach Online

    Social Media Expert And Founder Of Aapno Rajasthan Durgesh Dhaker Gives His Two Cents On Growing One's Reach Online

    “Work and you’ll get what you need; work harder and you’ll get what you want”.

    The above-mentioned quote speaks volumes about the courage of those who have made substantial breakthroughs in their life with hardwork and dedication.

    One such committed individual who is preparing several notable names with their social media reach is Durgesh Dhaker. An agile and someone who keeps himself upbeat with the happenings in the country, Durgesh has acquired expertise in carving the social media strategies for various stalwarts. He is also the founder of Aapno Rajasthan

    facebook page with more than 1 million likes which he gain within very short time with his expertise.

    Coming from the beautiful city of Chittorgarh in the land of Rajasthan, Durgesh Dhaker is making his parents and fellows pride of his strides and success acquired through hustling with perseverance. His social media expertise enables him to give his top tips for growing one’s social media presence, it is as below-

    1-Create a network

    Social media comprises of a huge number of people who need to build their reach, subsequently, it turns into a fiercely cutthroat spot where every individual is attempting to draw in mass consideration, thus it is basic that we upgrade our activities to pick a specialty which suits our inclinations, it ought to be something that you are prepared to deal with for quite a while of your life.

    Zero in on making an intuitive substance that can be discovered when somebody looks for it, the most ideal approach to do is to is utilize significant hashtags on Facebook, Twitter, etc.

    2-Create steady, quality posts that are relatable

    Today, the web has enough data however we can help our supporters discover quality data that isn’t excess by posting relatable substance according to our niche, recall, forthright, valuable, and quality substance is as yet restricted on the web, consequently assuming you give individuals what they are searching for reliably, gradually and slowly, you will see considerable development in individuals who follow you.

    3-Social media showcasing/connecting websites

    Social media marketing is perhaps the most ideal approach to get ideal reach online, to see speedy outcomes, posting cool videos, and opinion on the latest happenings are some methods which can be deployed. If one has a website on their name or related to their field of work then those can be attached on social media profiles to promote them better.

    In a nutshell, we can conclude that, according to Durgesh Dhaker, the top way to grow your social media presence is by being relevant and consistent with the content that is suited to the tastes of your target audience, linking several web pages and blogs to boost traffic and last but not the least correct marketing of your content that can lead to conversions.

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