Breakthrough in research for treatment of Parkinson’s disease by DU


By Ganesh Bhatt
New Delhi, July 12 |
Parkinson’s disease (PD) is a neuro-degenerative disorder and over 10 million people worldwide are affected by this with no drug available for its treatment. However, the University of Delhi has now identified a special protein, which makes it possible to treat this disease. McLean Hospital, Boston is a partner of the University of Delhi in this research.

The common symptoms of PD are tremor, rigidity, slowness of movement and difficulty in walking, which causes cognitive and behavioural problems such as depression, anxiety, and apathy.

The primary reason for this disease is the death of neuron cells in the substantia nigra (SN), which is located in the mid-brain, and it causes deficiency of dopamine, which plays several important roles in the brain and body.

Prof D.S. Rawat of the Department of Chemistry, University of Delhi said, “there are some proteins that are essential for the survival of Dopamine neurons. All it requires is to have healthy dopamine neurons to overcome this disease and Nurr1 protein maintains the healthy dopamine neurons and also protects the neurons from inflammation in case of PD and other neuro-degenerative diseases. So we thought this can be a target for the development of a drug for Parkinson’s disease.”

Rawat said, “all we needed was a molecule that can activate the Nurr1 protein which in turn can maintain healthy Dopamine neurons.”

A research group led by Prof Rawat started collaboration with Prof Kim at McLean Hospital, Boston and in 2014 this work was funded by MJ Fox Foundation. A formal MoU was signed between the University of Delhi and the McLean Hospital, Boston, US which resulted in a joint US patent and PCT application.

A massive synthetic programme was initiated at Delhi University and over 650 new compounds were synthesized by the team members namely Mohit Tripathi, Sunny Manohar, Satya V. Pavan, Rohit Kholiya, Shameer and Anuj Thakur.

All these compounds were screened for their Nurr1 activation potential. Interestingly, these compounds activate the Nurr1 protein that is essential for the good health of dopamine neurons, hence reduces the chances of Parkinson’s disease. These molecules, along with chloroquine and amodiaquine, which were identified in the initial screening, were experimentally demonstrated to bind and activate the Nurr1 and improve the PD related symptoms in a rat model to a great extent without any toxicity.

The University of Delhi and McLean Hospital have signed a technology transfer agreement with NurrOn Pharmaceuticals, Boston, for the development of these molecules as novel disease-modifying drugs for the treatment of Parkinson’s disease.

Source: IANS

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Share Market Closing Bell: Market ends marginally lower amid volatility

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Dalal Street witnessed tug of war between bulls and bears as Sensex settled at 54208.53 losing 109 points or 0.20 percent and Nifty ended at 16240.30 with loss of 19 points. Bank nifty closed the session at 34163.70 levels with loss of 138 point after erasing early session gain.

BSE Midcap and BSE Small cap indices turned flat after rising around half a percent each. On the sectorial front, Nifty Pharma and FMCG have contributed a percent each on a closing basis. On the flip side Nifty Realty, Nifty PSE ended with losses of 1.75 percent and 1.73 respectively. In Nifty stocks, TATACONSUM, CIPLA and ADANI PORT were the top gainers while POWERGRID, BPCL and TECHM were the prime laggards.

In the daily chart Nifty has ended with a bearish candle. However 16200 levels are protected throughout the day. Index might face high volatility on weekly expiry day. Riding against the trend may not be beneficial for short term traders. According to volume profile 16100 and 16000 may act as immediate support.

Indicators such as MACD and RSI are still struggling to overcome from oversold zone in the daily time frame. From the time cycle prospect Index would remain highly volatile till 27th May of this month. Bollinger band indicates 16650 would remain strong resistance in coming days. On the other hand, Bank nifty has support at 33400 levels while resistance at 35000 levels.

Om Mehra
Research Associate
Choice Broking

Source: Choice India


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