Australian researchers discover clues to severe Covid-19 in kids

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Sydney, May 3 | Researchers in Australia have discovered the blood clotting and immune protein pathways that are activated in severe cases of Covid-19 in children, paving the way for earlier diagnosis and more targeted treatments.

The team at the Murdoch Children’s Research Institute (MCRI) and the University of Melbourne identified disease mechanisms in children with Covid who present with multisystem inflammatory syndrome, where different body parts can become inflamed including the heart, lungs, and brain and acute respiratory distress syndrome, a type of lung disease.

The findings, published in the journal Nature Communications, showed the main triggers for severe Covid in children were blood clotting and how proteins in the immune system reacted to the virus.

“Children are in general less susceptible to Covid-19 and present with milder symptoms, but it remained unclear what caused some to develop very severe disease,” said Conor McCafferty, a researcher and doctoral student at the MCRI.

For the study, blood samples from 20 healthy children and samples from 33 SARS-CoV-2 infected children with multisystem inflammatory syndrome or acute respiratory distress syndrome were collected.

The team found 85 and 52 proteins were specific to multisystem inflammatory syndrome and acute respiratory distress syndrome, respectively. Both syndromes are major potential outcomes of severe Covid.

Data shows 1.7 per cent of reported paediatric hospitalised cases of Covid included admission to the Intensive Care Unit.

Children with Covid who present with multisystem inflammatory syndrome also show similar clinical features to Kawasaki disease and toxic shock syndrome such as fever, abdominal pain, vomiting, skin rash and conjunctivitis, making it difficult to quickly diagnose patients.

MCRI Professor Vera Ignjatovic said the results provided an understanding of the processes that underlie severe Covid-19 in children, which would help in the development of diagnostic tests for early identification of children at risk, as well as therapeutic targets to improve the outcomes for those with severe cases.

“Knowing the mechanisms associated with severe Covid-19 in children and how the blood clotting and immune systems in children react to the virus will help diagnose and detect acute Covid-19 cases and allow us to develop targeted treatment,” she said.

Source: IANS

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Weekly Technical Share Market Outlook

Weekly Technical Share Market Outlook

The Indian market recovered sharply on the last trading day amid the weekend after a continuous fall. Market has managed to halt above 16000 Nifty levels after continuous losing streak. Index reacted violently, grasping Indian as well as global factors throughout the week. Simultaneously, Inflation is catching up and profit margins are taking a hit.

 

Sensex advanced 1532 points or 2.90 percent while Nifty gained 484 points or 3.07 percent in a week. Simultaneously, Bank nifty has overcome bear’s dominance ending the session with 3.49 percent gain. Sectorally,Nifty Metal saw the highest gains of 7.40 percent followed by the Realty and Auto added over 4% gain. On the flip side Nifty IT tumbled 2.82 percent on weekly basis. Midcap and Small Cap measures rising nearly 2 percent as well.

In Nifty stock, EICHERMOT gained 11.31% while TECHM lost 5.98% on a weekly basis. INDIA VIX closes at 23.10 suggests volatility driven market is going to remain intact. Coming to the OI Data, on the call side highest OI witnessed at 17000 Nifty followed by 16800 Nifty strike price while on the put side, the highest OI was at 16000 Nifty followed by 15800 Nifty strike price. Technically, Nifty has formed a Tweezer Bottom type pattern in the weekly chart suggesting a short term buying rally may drive the market until monthly expiry. On the daily chart, price has rebounded from the lower Bollinger band as well.

Momentum indicators MACD & Stochastic were trading with a positive crossover & reversed from oversold zone. However, Index is still struggling to get the support of 50 Simple Moving Average in daily chart. Short term investors and traders are advised to work with option strategies to neutralize the volatility. Overall, Nifty is having support at 15700 mark while on the upside 16700 followed by 16500 may act as an immediate resistance. While Bank nifty has support around 32500 while resistance is placed at 36000 on weekly chart.

Sumeet Bagadia
Executive Director
Choice Broking

Source: Choice India

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